I had a virtumonde spyware infection - it also showed up as Vundo. I tried all kinds of scanners to get rid of it, but it always came back after rebooting. Lots of people end up reformatting their hard drives and re-installing to get rid of this thing.
Turns out it was residing inside my Java runtime environment. I think it was pretty disappointing that the spyware scanning sites didn't talk about this because there are people that seem to be well aware of it and I have to believe the spyware scanners know this is a possibility too.
The solution was to remove all instances of Java from my system and install a fresh release and scan with a couple products. Spybot S&D and SuperAntiSpyware. In general, SAS seems to do a better job.
So far so good.